Corestemchemon Inc
Corestemchemon Inc

GLP Certification

Inspection agency	Korea Food & Drug Administration
Date of Initial accreditation	August 12, 2002
Inspection list	Inspection for KGLP Application Test
Inspection result	Designated as the non-clinical testing institution pursuant to the Article iv of Good Laboratory Practice (GLP) standard
Area of the tests	Single-dose toxicity test (excluding inhalation exposure) Repeated Dose toxicity test (excluding inhalation exposure) Reproductive and Developmental Toxicology Genetic toxicity - Chromosome aberration test - Micronucleus test - in vitro Mammalian Cell Gene Mutation test Using the Thymidine Kinase Gene,  in vivo comet assay Ames test(Bacterial Revers mutation test) Local Lymph Node Assay: BrdU-ELISA In vitro eye irritation and damage test(human cornea model test) In vitro skin irritation test (human skin model test) In vitro 3T3 NRU phototoxicity test Antigenicity test Carcinogenicity test Local toxicity test Local tolerance test Analytical Test - Analytical test during toxicokinetic study - Other analysis tests Others toxicity tests(phototoxicity/photosesitization) Safety Pharmacology test - Assessment of effects on the central nervous system - respiratory system cardiovascular system - Telemetry - hERG assay - Nav 1.5 (sodium channel) test - Cav 1.2 (calcium channel) test - hiPSC-CMs-based multi-electrode measurement test(MEA) test Medical device part - In vitro genotoxicity - In vivo genotoxicity - In vitro cytotoxicity (extracts test, Test by direct contract, Test by indirect contract) - Skin sensitization test - intradermal reactivity test - Guinea pig assay for the detection of Skin sensitization - Acute systemic toxicity

Inspection agency	Ministry of Environment
Date of Initial accreditation	September 3, 2008
Inspection list	An inspection for designating the chemical toxicity testing institution
Inspection result	Designated as chemical toxicity testing institution (GLP testing institution) according to the Article 14 of the Toxic Chemicals Control Act, pursuant to Article 12 and Section 2 of Article 10
Area of the tests	Acute oral toxicity/ Acute dermal toxicity Eye irritation Subacute oral toxicity/ Subacute dermal toxicity Chromosome aberration test Ames test(Bacterial Revers mutation test) Micronucleus test Local Lymph Node Assay-BrdU-ELISA Reproductive toxicity test Skin irritation Skin sensitization Chronic toxicity test Teratogenicity test Carcinogenicity test Combined chronic toxicity/ carcinogenicty test Algae growth inhibition Daphinia magna reproduction toxicity Fish acute toxicity

Inspection agency	Rural Development Administration
Date of Initial accreditation	June 8, 2008
Inspection list	An inspection for designating the research institute of Agricultural Chemicals Safety Test
Inspection result	Designated as Agricultural Chemicals Safety Test research institute (GLP institution) pursuant to the Article iv
Area of the tests	Acute oral/dermal toxicity Acute dermal irrtation/corrosion Acute eye irrtation/corrosion Skin sensitization Genetix toxicity (Ames test, Chromosome aberration test, Micronucleus test, in vivo comet assay) Subacute/Chronic toxicity Two-generation reproduction toxicity Teratogenicity Carcinogenicity Alga growth inhibition Test Daphnia sp. Acute immobilization Test Fish acute toxicity Test Local Lymph Node Assay: BrdU-ELISA In vivo Skin Irritation: Reconstructed Human Epidermis Test In vitro Eye Irritation: Reconstructed Human Corea-like Epithelum (RhCE) Test Genetic toxicity (In vitro Mammalian Gene Mutation Test) Local Lymph Node Assay: BrdU-ELISA In vitro 3T3 NRU Phototoxicity Test

AAALAC Accreditation Status

Accreditation Institution Name	Accreditation Date
	March 2, 2010

Animal Research Facility Registration status

Accreditation Institution Name	No.	Accreditation Date
	No.15	November 16, 2009

Good Animal Research Facility Designation Status

Accreditation Institution Name	No.	Accreditation Date
	No.7	November 12, 2013

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